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dc.contributor.authorAguayo, Encarna
dc.contributor.authorMartínez-Sánchez, Ascensión
dc.contributor.authorFernández-Lobato, Bárbara
dc.contributor.authorAlacid, Fernando
dc.date.accessioned2021-04-19T09:11:56Z
dc.date.available2021-04-19T09:11:56Z
dc.date.issued2021-04-06
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10835/10497
dc.description.abstractL-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is watermelon, is a non-essential amino acid but which has important health potential. This review provides a comprehensive approach to different studies of the endogenous synthesis of CIT, metabolism, pharmacokinetics, and pharmacodynamics as well as its ergogenic effect in exercise performance. The novel aspect of this paper focuses on the different effects of CIT, citrulline malate and CIT from natural sources such as watermelon on several topics, including cardiovascular diseases, diabetes, erectile dysfunction, cancer, and exercise performance. CIT from watermelon could be a natural food-sourced substitute for pharmacological products and therefore the consumption of this fruit is promoted.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectfunctional foodes_ES
dc.subjectbio-active compoundses_ES
dc.subjectsport performancees_ES
dc.subjectphytochemicalses_ES
dc.subjectwatermelones_ES
dc.subjectmuscle fatiguees_ES
dc.subjectergogenic aidses_ES
dc.titleL-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Healthes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/11/7/3293es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional