Short, medium, and long-term behavioral and molecular effects of the preweaning exposure to Chlorpyrifos in Wistar rats.
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Author/sPérez Fernández, Cristian
Chlorpyrifos (CPF) is one of the most widely used Organophosphate pesticides (OP) in both developed and developing countries. Although its importance FOR human needs is unquestionable, its use has been systematically linked with several specific behavioral and physiological alterations, as well as with the incidence of numerous psychiatric, neurologic, neurodevelopmental, and neurodegenerative disorders. Even though the main mechanism of toxicology of CPF is the irreversible inhibition of Acetylcholinesterases (AChE) in the central nervous system (CNS), several authors have found alternative molecular targets (e.g., different components within the cholinergic system and from other neurotransmitter systems) without the implication of AChE by using doses wellbellow the range of systemic inhibition, defining a non-cholinesterase profile of neurotoxicology (NChEI). Interestingly, this profile has primarily been observed following developmental exposure protocols when the immature CNS appea...
behavioral and molecular effects
Chlorpyrifos in Wistar rats
efectos conductuales y moleculares