Mostrar el registro sencillo del ítem

dc.contributor.authorBiosca-Brull, Judit
dc.contributor.authorPérez-Fernández, Cristian
dc.contributor.authorMora, Santiago
dc.contributor.authorCarrillo, Beatriz
dc.contributor.authorPinos, Helena
dc.contributor.authorConejo, Nelida Maria
dc.contributor.authorCollado, Paloma
dc.contributor.authorArias, Jorge L.
dc.contributor.authorMartín-Sánchez, Fernando
dc.contributor.authorSánchez-Santed, Fernando
dc.contributor.authorColomina, Maria Teresa
dc.date.accessioned2021-07-22T08:28:26Z
dc.date.available2021-07-22T08:28:26Z
dc.date.issued2021-05-13
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10835/12024
dc.description.abstractAutism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectautism spectrum disorderes_ES
dc.subjectsociabilityes_ES
dc.subjectpesticidees_ES
dc.subjectorganophosphatees_ES
dc.subjectcarbamateses_ES
dc.subjectorganochlorinees_ES
dc.subjectchlorpyrifoses_ES
dc.titleRelationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Modelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/10/5190es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional