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dc.contributor.authorFerrer Donato, Agueda
dc.contributor.authorContreras, Ana
dc.contributor.authorFrago, Laura M.
dc.contributor.authorChowen, Julie A.
dc.contributor.authorFernandez-Martos, Carmen M.
dc.date.accessioned2021-10-04T10:50:32Z
dc.date.available2021-10-04T10:50:32Z
dc.date.issued2021-09-24
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10835/12369
dc.description.abstractLeptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disease. This adipokine has previously been shown to be associated with a lower risk of ALS and to confer a survival advantage in ALS patients. However, the role of leptin in the progression of ALS is unknown. Indeed, our understanding of the mechanisms underlying leptin’s effects in the pathogenesis of ALS is very limited, and it is fundamental to determine whether alterations in leptin’s actions take place in this neurodegenerative disease. To characterize the association between leptin signaling and the clinical course of ALS, we assessed the mRNA and protein expression profiles of leptin, the long-form of the leptin receptor (Ob-Rb), and leptin-related signaling pathways at two different stages of the disease (onset and end-stage) in TDP-43A315T mice compared to age-matched WT littermates. In addition, at selected time-points, an immunoassay analysis was conducted to characterize plasma levels of total ghrelin, the adipokines resistin and leptin, and metabolic proteins (plasminogen activator inhibitor type 1 (PAI-1), gastric inhibitory peptide (GIP), glucagon-like peptide 1 (GLP-1), insulin and glucagon) in TDP-43A315T mice compared to WT controls. Our results indicate alterations in leptin signaling in the spinal cord and the hypothalamus on the backdrop of TDP-43-induced deficits in mice, providing new evidence about the pathways that could link leptin signaling to ALS.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectneurodegenerative diseasees_ES
dc.subjectamyotrophic lateral sclerosis (ALS)es_ES
dc.subjectmetabolismes_ES
dc.subjectleptines_ES
dc.subjectlong leptin receptor (Ob-Rb)es_ES
dc.subjectTAR DNA binding protein (TDP-43)es_ES
dc.titleAlterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/19/10305es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doihttps://doi.org/10.3390/ijms221910305


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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