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Unprecedented Elimination Reactions of Cyclic Aldols: A New Biosynthetic Pathway toward the Taiwaniaquinoid Skeleton
dc.contributor.author | Guardia, Juan J. | |
dc.contributor.author | Fernández, Antonio | |
dc.contributor.author | Justicia, José | |
dc.contributor.author | Zentar, Houda | |
dc.contributor.author | Alvarez-Manzaneda Roldán, Ramón Jesús | |
dc.contributor.author | Alvarez-Manzaneda, Enrique | |
dc.contributor.author | Chahboun, Rachid | |
dc.date.accessioned | 2023-02-09T14:58:49Z | |
dc.date.available | 2023-02-09T14:58:49Z | |
dc.date.issued | 2023-02-04 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | http://hdl.handle.net/10835/14223 | |
dc.description.abstract | The acid treatment of 6,7-seco-abietane dialdehydes gives, in high yield, the corresponding derivatives with the 4a-methyltetrahydrofluorene skeleton of taiwaniaquinoids. A mechanism involving the elimination of formic acid from the cyclic aldol intermediate is proposed here. This process can be postulated as a new biogenetic pathway from abietane diterpenes to taiwaniaquinoids. Using this novel reaction, the first enantiospecific synthesis of bioactive natural cupresol and taxodal has been obtained. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | bioactive natural products | es_ES |
dc.subject | synthesis | es_ES |
dc.subject | diterpenoids | es_ES |
dc.subject | taiwaniaquinoids | es_ES |
dc.title | Unprecedented Elimination Reactions of Cyclic Aldols: A New Biosynthetic Pathway toward the Taiwaniaquinoid Skeleton | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/28/4/1524 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/molecules28041524 |