Unified Method for Target and Non-Target Monitoring of Pesticide Residues in Fruits and Fruit Juices by Gas Chromatography-High Resolution Mass Spectrometry
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Author/sGranados Povedano, Mireya; Dóminguez Pérez, Irene; Egea González, Francisco Javier; Garrido Frenich, Antonia; Arrebola Liébanas, Francisco Javier
A new polyvalent wide-scope analytical method, valid for both raw and processed (juices) fruits, combining target and non-target strategies, has been developed and validated to determine low concentrations of 260 pesticides, as well as many potential non-target substances and metabolites. The target approach has been validated according to SANTE Guide requirements. Trueness, precision, linearity, and robustness values were validated in raw fruit (apple) and juice (apple juice) as representative solid and liquid food commodities. Recoveries were between 70–120% and two ranges of linearity were observed: 0.5–20 μg kg−1 (0.5–20 μg L−1 apple juice) and 20–100 μg kg−1 (20–100 μg L−1 apple juice). The limits of quantification (LOQs) reached were lower than 0.2 μg kg−1 in apple (0.2 μg L−1 apple juice) in most cases. The developed method, based on QuEChERS extraction followed by gas chromatography-high resolution mass spectrometry (GC-HRMS), achieves part-per-trillions lower limits, which all...
GC-Q-Exactive Orbitrap MS