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Binding ability properties of β-cyclodextrin dimers linked through their secondary faces towards cancer chemotherapeutic agent methotrexate

dc.contributor.authorAykac, Ahmet 
dc.contributor.authorMartos Maldonado, Manuel Cristo 
dc.contributor.authorCasas Solvas, Juan Manuel 
dc.contributor.authorGarcía Fuentes, Luis Sebastián 
dc.contributor.authorVargas Berenguel, Antonio 
dc.date.accessioned2024-03-14T08:28:20Z
dc.date.available2024-03-14T08:28:20Z
dc.date.issued2012-04-10
dc.identifier.citationJ. Drug Deliv. Sci. Tech. 2012, 22, 270-272es_ES
dc.identifier.issn1773-2247
dc.identifier.urihttp://hdl.handle.net/10835/16155
dc.description.abstractThe binding ability properties of two β-cyclodextrin dimers linked through their secondary faces by short, rigid spacer arms towards the cancer chemotherapeutic agent methotrexate were studied by ITC and NMR (1D and ROESY) experiments. Both dimers are able to bind two molecules of methotrexate with a binding constant between 2.4 and 3.5 times higher than that for native β-cyclodextrin, the dimer having the shortest linker forming the most stable complex.es_ES
dc.language.isoenes_ES
dc.publisherElsevier B.V.es_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectβ-Cyclodextrin dimerses_ES
dc.subjectComplexation abilityes_ES
dc.subjectMethotrexatees_ES
dc.subjectSolubilityes_ES
dc.subjectCalorimetryes_ES
dc.subjectNMRes_ES
dc.subjectBinding constantses_ES
dc.titleBinding ability properties of β-cyclodextrin dimers linked through their secondary faces towards cancer chemotherapeutic agent methotrexatees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1773224712500390es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1016/S1773-2247(12)50039-0
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/237962es_ES


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