CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties.

Abstract

Complexes [RuCp(Adeninate-κN9)(PTA)2] (1), [RuCp- (Guaninate-κN9)(PTA)2] (2), [RuCp(Theophyllinate-κN7)(PTA)2] (3), [RuCp(Adeninate-κN9)(PPh3)(PTA)] (4), [RuCp(Guaninate- κN9)(PPh3)(PTA)] (5) and [RuCp(Theophyllinate-κN7)(PPh3)(PTA)] (6) were synthesized and characterized by NMR spectroscopy, elemental analysis and FT-IR (PTA = 1,3,5-triaza-7-phosphaadamantane). Crystal structures of 1·H2O·3EtOH, 3·CH3COCH3 and 4·H2O were also determined by single-crystal X-ray diffraction. The antiproliferative activities of the complexes against cisplatin-sensitive T2 and cisplatin-resistant SKOV3 cell lines have also been evaluated. Theoretical studies were preformed to elucidate how the adeninate ligand is coordinated to the metal.