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dc.contributor.authorCutrone, Giovanna
dc.contributor.authorLi, Xue
dc.contributor.authorCasas Solvas, Juan Manuel
dc.contributor.authorMenendez Miranda, Mario
dc.contributor.authorQiu, Jingwen
dc.contributor.authorBenkovics, Gábor
dc.contributor.authorConstantin, Doru
dc.contributor.authorMalanga, Milo
dc.contributor.authorMoreira Alvarez, Borja
dc.contributor.authorCosta Fernández, José Manuel
dc.contributor.authorGarcía Fuentes, Luis
dc.contributor.authorGref, Ruxandra
dc.contributor.authorVargas Berenguel, Antonio
dc.date.accessioned2020-01-17T08:12:34Z
dc.date.available2020-01-17T08:12:34Z
dc.date.issued2019-08-01
dc.identifier.issn2079-4991
dc.identifier.urihttp://hdl.handle.net/10835/7493
dc.description.abstractNanosized metal-organic frameworks (nanoMOFs) MIL-100(Fe) are highly porous and biodegradable materials that have emerged as promising drug nanocarriers. A challenging issue concerns their surface functionalization in order to evade the immune system and to provide molecular recognition ability, so that they can be used for specific targeting. A convenient method for their coating with tetraethylene glycol, polyethylene glycol, and mannose residues is reported herein. The method consists of the organic solvent-free self-assembly on the nanoMOFs of building blocks based on β-cyclodextrin facially derivatized with the referred functional moieties, and multiple phosphate groups to anchor to the nanoparticles’ surface. The coating of nanoMOFs with cyclodextrin phosphate without further functional groups led to a significant decrease of macrophage uptake, slightly improved by polyethylene glycol or mannose-containing cyclodextrin phosphate coating. More notably, nanoMOFs modified with tetraethylene glycol-containing cyclodextrin phosphate displayed the most efficient “stealth” effect. Mannose-coated nanoMOFs displayed a remarkably enhanced binding affinity towards a specific mannose receptor, such as Concanavalin A, due to the multivalent display of the monosaccharide, as well as reduced macrophage internalization. Coating with tetraethylente glycol of nanoMOFs after loading with doxorubicin is also described. Therefore, phosphorylated cyclodextrins offer a versatile platform to coat nanoMOFs in an organic solvent-free, one step manner, providing them with new biorecognition and/or “stealth” properties.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmetal-organic frameworkses_ES
dc.subjectMIL-100(Fe)es_ES
dc.subjectβ-cyclodextrines_ES
dc.subjectmannosees_ES
dc.subjectmolecular recognitiones_ES
dc.subject“stealth” effectes_ES
dc.subjectmultivalent effectes_ES
dc.subjectisothermal titration calorimetryes_ES
dc.subjectmacrophagees_ES
dc.titleDesign of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Mediaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/2079-4991/9/8/1103es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional