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dc.contributor.authorSoriano Maldonado, Alberto
dc.contributor.authorMorillas de Laguno, Pablo
dc.contributor.authorSabio, José Mario
dc.contributor.authorGavilán Carrera, Blanca
dc.contributor.authorRosales Castillo, Antonio
dc.contributor.authorMontalbán Méndez, Cristina
dc.contributor.authorSáez Urán, Luis Manuel
dc.contributor.authorCallejas Rubio, José Luis
dc.contributor.authorVargas Hitos, José Antonio
dc.date.accessioned2020-01-17T09:59:52Z
dc.date.available2020-01-17T09:59:52Z
dc.date.issued2018-11-24
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10835/7536
dc.description.abstractThis study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN-α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference −0.034, 95% CI −0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectexercisees_ES
dc.subjectphysical fitnesses_ES
dc.subjectaerobic fitnesses_ES
dc.subjectphysical functiones_ES
dc.subjectpulse wave velocityes_ES
dc.subjectautoimmune diseaseses_ES
dc.subjectvascular healthes_ES
dc.subjectatherosclerosises_ES
dc.subjectlupuses_ES
dc.subjectinflammatory diseasees_ES
dc.titleEffects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Triales_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/7/12/477es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional