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dc.contributor.authorMartos Maldonado, Manuel Martos
dc.contributor.authorQuesada Soriano, Indalecio 
dc.contributor.authorGarcía Fuentes, Luis
dc.contributor.authorVargas Berenguel, Antonio 
dc.date.accessioned2020-02-19T08:16:30Z
dc.date.available2020-02-19T08:16:30Z
dc.date.issued2020-01-24
dc.identifier.issn2079-4991
dc.identifier.urihttp://hdl.handle.net/10835/7696
dc.description.abstractGalectin-3 is considered a cancer biomarker and bioindicator of fibrosis and cardiac remodeling and, therefore, it is desirable to develop convenient methods for its detection. Herein, an approach based on the development of multivalent electrochemical probes with high galectin-3 sensing abilities is reported. The probes consist of multivalent presentations of lactose–ferrocene conjugates scaffolded on poly (amido amine) (PAMAM) dendrimers and gold nanoparticles. Such multivalent lactose–ferrocene conjugates are synthesized by coupling of azidomethyl ferrocene–lactose building blocks on alkyne-functionalized PAMAM, for the case of the glycodendrimers, and to disulfide-functionalized linkers that are then used for the surface modification of citrate-stabilized gold nanoparticles. The binding and sensing abilities toward galectin-3 of both ferrocene-containing lactose dendrimers and gold nanoparticles have been evaluated by means of isothermal titration calorimetry, UV–vis spectroscopy, and differential pulse voltammetry. The highest sensitivity by electrochemical methods to galectin-3 was shown by lactosylferrocenylated gold nanoparticles, which are able to detect the lectin in nanomolar concentrations.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectgalectin-3es_ES
dc.subjectelectrochemical probeses_ES
dc.subjectgold nanoparticleses_ES
dc.subjectferrocenees_ES
dc.subjectelectroactive glycodendrimerses_ES
dc.subjectPAMAMes_ES
dc.titleMultivalent Lactose–Ferrocene Conjugates Based on Poly (Amido Amine) Dendrimers and Gold Nanoparticles as Electrochemical Probes for Sensing Galectin-3es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/2079-4991/10/2/203es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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