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dc.contributor.authorPlatero, Jose Luis
dc.contributor.authorCuerda Ballester, María
dc.contributor.authorIbáñez, Vanessa
dc.contributor.authorSancho, David
dc.contributor.authorLópez Rodríguez, María Del Mar
dc.contributor.authorDrehmer, Eraci
dc.contributor.authorRubia Ortí, Jose Enrique de la
dc.date.accessioned2020-02-19T08:38:06Z
dc.date.available2020-02-19T08:38:06Z
dc.date.issued2020-01-23
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10835/7702
dc.description.abstractBackground: Due to the inflammatory nature of multiple sclerosis (MS), interleukin 6 (IL-6) is high in blood levels, and it also increases the levels of anxiety related to functional disability. Epigallocatechin gallate (EGCG) decreases IL-6, which could be enhanced by the anti-inflammatory effect of high ketone bodies after administering coconut oil (both of which are an anxiolytic). Therefore, the aim of this study was to assess the impact of coconut oil and EGCG on the levels of IL-6, anxiety and functional disability in patients with MS. Methods: A pilot study was conducted for four months with 51 MS patients who were randomly divided into an intervention group and a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, and the control group was prescribed a placebo. Both groups followed the same isocaloric Mediterranean diet. State and trait anxiety were determined before and after the study by means of the State-Trait Anxiety Inventory (STAI). In addition, IL-6 in serum was measured using the ELISA technique and functional capacity was determined with the Expanded Disability Status Scale (EDSS) and the body mass index (BMI). Results: State anxiety and functional capacity decreased in the intervention group and IL-6 decreased in both groups. Conclusions: EGCG and coconut oil improve state anxiety and functional capacity. In addition, a decrease in IL-6 is observed in patients with MS, possibly due to the antioxidant capacity of the Mediterranean diet and its impact on improving BMI.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmultiple sclerosises_ES
dc.subjectepigallocatechin gallatees_ES
dc.subjectcoconut oiles_ES
dc.subjectinterleukin-6es_ES
dc.subjectanxietyes_ES
dc.subjectdisabilityes_ES
dc.titleThe Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/12/2/305es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional