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dc.contributor.authorBenlloch, María
dc.contributor.authorCuerda Ballester, María
dc.contributor.authorDrehmer, Eraci
dc.contributor.authorPlatero, Jose Luis
dc.contributor.authorCarrera Juliá, Sandra
dc.contributor.authorLópez Rodríguez, María Mar
dc.contributor.authorCeron, Jose Joaquin
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorNavarro, Marí Ángeles
dc.contributor.authorMoreno, Mari Luz
dc.contributor.authorRubia Ortí, Jose Enrique de la
dc.date.accessioned2020-12-18T08:51:23Z
dc.date.available2020-12-18T08:51:23Z
dc.date.issued2020-12-10
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10835/9172
dc.description.abstractMultiple sclerosis (MS) is a neurodegenerative disease that causes anthropometric changes characterised by functional disability, increase in fat mass, and decrease in lean mass. All these variables are related to a greater cardiac risk. The polyphenol epigallocatechin gallate (EGCG) and an increase in ketone bodies in the blood have been shown to have beneficial effects on anthropometric and biochemical variables related to cardiovascular activity. The aim of this study was to analyse the impact of the intervention with EGCG and ketone bodies on cardiac risk in MS patients. A population of 51 MS patients were randomly assigned to a control group and an intervention group (daily dose of 800 mg of EGCG and 60 mL of coconut oil). Both groups followed an isocaloric diet for 4 months. Levels of beta-hydroxybutyrate (BHB), albumin, paraoxonase 1 (PON1) and C-reactive protein (CRP) were measured in serum before and after the intervention, as well as determining functional ability, waist circumference, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), fat percentage and muscle percentage. After 4 months, in the intervention group there was a significant increase in BHB, PON1 and albumin, while CRP did not vary; a significant decrease in cardiac risk associated with a significant decline in WHR; as well as a significant increase in muscle percentage. By contrast, these changes were not observed in the control group. Finally, results from analysis of variance (ANOVA) revealed a significant time–condition interaction effect, observing that WHtR and fat mass decreased in the intervention group, while they increased in the control group.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmultiple sclerosises_ES
dc.subjectcardiac riskes_ES
dc.subjectepigallocatechin gallatees_ES
dc.subjectketone bodieses_ES
dc.titlePossible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/12/12/3792es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional