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dc.contributor.authorGuardia Escote, Laia
dc.contributor.authorBlanco, Jordi
dc.contributor.authorBasaure, Pia
dc.contributor.authorBiosca Brull, Judit
dc.contributor.authorVerkaik Schakel, Rikst Nynke
dc.contributor.authorCabré, Maria
dc.contributor.authorPeris Sampedro, Fiona
dc.contributor.authorPérez Fernández, Cristian
dc.contributor.authorSánchez Santed, Luis Fernando
dc.contributor.authorPlösch, Torsten
dc.contributor.authorDomingo, José L.
dc.contributor.authorColomina, Maria Teresa
dc.date.accessioned2021-01-11T11:26:43Z
dc.date.available2021-01-11T11:26:43Z
dc.date.issued2020-12-29
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10835/9278
dc.description.abstractDevelopmental exposure to toxicants and diet can interact with an individual’s genetics and produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF). We aimed to study the epigenetic regulation on feeding control genes and the influence of postnatal CPF exposure, APOE genotype, and sex, and how these modifications impact on the metabolic response to a high-fat diet (HFD). Both male and female apoE3- and apoE4-TR mice were exposed to CPF on postnatal days 10–15. The DNA methylation pattern of proopiomelanocortin, neuropeptide Y, leptin receptor, and insulin-like growth factor 2 was studied in the hypothalamus. At adulthood, the mice were given a HFD for eight weeks. The results highlight the importance of sex in the epigenetic regulation and the implication of CPF treatment and APOE genotype. The body weight progression exhibited sex-dimorphic differences, apoE4-TR males being the most susceptible to the effects induced by CPF and HFD. Overall, these results underscore the pivotal role of sex, APOE genotype, and developmental exposure to CPF on subsequent metabolic disturbances later in life and show that sex is a key variable in epigenetic regulation.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectchlorpyrifoses_ES
dc.subjectAPOEes_ES
dc.subjectepigeneticses_ES
dc.subjectfeeding controles_ES
dc.subjecthigh-fat dietes_ES
dc.titleSex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Dietes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/1/184es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional