Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS)
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Ferrer Donato, Agueda; Contreras, Ana; Frago, Laura M.; Chowen, Julie A.; Fernandez-Martos, Carmen M.Date
2021-09-24Abstract
Leptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disease. This adipokine has previously been shown to be associated with a lower risk of ALS and to confer a survival advantage in ALS patients. However, the role of leptin in the progression of ALS is unknown. Indeed, our understanding of the mechanisms underlying leptin’s effects in the pathogenesis of ALS is very limited, and it is fundamental to determine whether alterations in leptin’s actions take place in this neurodegenerative disease. To characterize the association between leptin signaling and the clinical course of ALS, we assessed the mRNA and protein expression profiles of leptin, the long-form of the leptin receptor (Ob-Rb), and leptin-related signaling pathways at two different stages of the disease (onset and end-stage) in TDP-43A315T mice compared to age-matched WT littermates. In addition, at selected time-points, an immunoassay analysis was conducted ...
Palabra/s clave
neurodegenerative disease
amyotrophic lateral sclerosis (ALS)
metabolism
leptin
long leptin receptor (Ob-Rb)
TAR DNA binding protein (TDP-43)