Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke
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Tsivgoulis, Georgios; Saqqur, Maher; Sharma, Vijay K; Brunser, Alejandro; Eggers, Jürgen; [et al.]Fecha
2020-02-25Resumen
Background and purpose: Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated with intravenous tissue plasminogen activator (tPA), the effect of the timing of tPA-induced recanalization on functional outcomes remains debatable.
Methods: We conducted a multicenter, prospective observational cohort study to determine whether early (within 1-hour from tPA-bolus) complete or partial recanalization assessed during 2-hour real-time transcranial Doppler monitoring is associated with improved outcomes in patients with proximal occlusions. Outcome events included dramatic clinical recovery (DCR) within 2 and 24-hours from tPA-bolus, 3-month mortality, favorable functional outcome (FFO) and functional independence (FI) defined as modified Rankin Scale (mRS) scores of 0-1 and 0-2 respectively.
Results: We enrolled 480 AIS patients (mean age 66±15 years, 60% men, baseline National Institutes of Health Stroke Scale score 15...
Palabra/s clave
Thrombolysis; Stroke; Reperfusion; Outcomes