Placido-based indices of corneal irregularity
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Author/sRamos López, Darío
Purpose: To construct a set of metrics computed from the raw keratoscopic data collected by any Placido corneal topographer. These indices that measure the irregularity of the anterior corneal surface are computed directly from the image of the mires reflected on the cornea, which is the most primary data possible. Besides the high sensitivity and specificity, this approach allows bypassing the surface or curvature reconstruction step that is currently performed by the software of any commercial Placido topographer. Methods: Several basic indices are proposed in order to detect irregularities on the anterior surface of the cornea, via analyzing some geometric and mathematical properties of the mires. These individual primary indices are built in a natural and intuitive way directly from the displacement of the digitized images of the rings reflected on the cornea. Additionally, compound indices are proposed (such as the generalized linear model or the classification tree...