Screening subclinical keratoconus with Placido-based corneal indices
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Author/sRamos López, Darío
Purpose: To assess in a sample of normal, keratoconic and keratoconus suspect eyes the performance of a set of new topographic indices computed directly from the digitized images of the Placido rings. Methods: This comparative study comprised a total of 124 eyes of 106 patients from the ophthalmic clinics Vissum Alicante and Vissum Almería (Spain), in three groups: control group (50 eyes), keratoconus group (50 eyes) and keratoconus suspect group (24 eyes). In all cases, a comprehensive examination was performed including the corneal topography with a Placido-based CSO topography system. Clinical outcomes were compared among groups, along with the discriminating performance of the proposed irregularity indices. Results: Significant differences at level 0.05 were found on the values of the indices among groups by means of Mann-Witney-Wilcoxon non-parametric test and Fisher’s exact test. Additional statistical methods, such as receiver operating characteristic analysis...