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dc.contributor.authorMorales Navas, Miguel
dc.contributor.authorCastaño Castaño, Sergio
dc.contributor.authorPérez Fernández, Cristian
dc.contributor.authorSánchez Gil, Ainhoa
dc.contributor.authorColomina, María Teresa
dc.contributor.authorLeinekugel, Xavier
dc.contributor.authorSánchez Santed, Fernando
dc.date.accessioned2020-09-14T07:14:28Z
dc.date.available2020-09-14T07:14:28Z
dc.date.issued2020-09-01
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10835/8437
dc.description.abstractBackground: In recent years, ultrasonic vocalizations (USV) in pups has become established as a good tool for evaluating behaviors related to communication deficits and emotional states observed in autism spectrum disorder (ASD). Prenatal valproic acid (VPA) exposure leads to impairments and social behavior deficits associated with autism, with the effects of VPA being considered as a reliable animal model of ASD. Some studies also suggest that prenatal exposure to chlorpyrifos (CPF) could enhance autistic-like behaviors. Methods: In order to explore these similarities, in the present study we tested whether prenatal exposure to CPF at GD12.5–14.5 produces effects that are comparable to those produced by prenatal VPA exposure at GD12.5 in infant Wistar rats. Using Deep Squeek software, we evaluated total number of USVs, latency to the first call, mean call duration, principal frequency peak, high frequency peak, and type of calls. Results: Consistent with our hypothesis, we found that exposure to both CPF and VPA leads to a significantly smaller number of calls along with a longer latency to produce the first call. No significant effects were found for the remaining dependent variables. Conclusions: These results suggest that prenatal exposure to CPF could produce certain behaviors that are reminiscent of those observed in ASD patients.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectautistic spectrum disorderes_ES
dc.subjectultrasonic vocalizationses_ES
dc.subjectchlorpyrifoses_ES
dc.subjectvalproic acides_ES
dc.subjectprenatal exposurees_ES
dc.subjectautismes_ES
dc.subjectorganophosphateses_ES
dc.titleSimilarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/17/17/6376es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional