In vitro antitumor activity of arachidonic and docosahexaenoic acids as both monoacylglycerols and free fatty acids on colorectal cancer cells
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Author/sGonzález Fernández, María José
Abstract Colorectal cancer (CRC) is one of the most common and mortal types of cancer. There is an increasing evidence that some polyunsaturated fatty acids (PUFA) are very effective as antitumor compounds on cancer cells through different mechanisms. PUFA occurs in the human body at different forms, from which monoacylglycerols (MAG) and free FA (FFA) promote important health benefits; for instance, they prevent the onset of CRC. This document is structured in three chapters: Chapter I is related to two articles corresponding to two different methodologies to obtain highly purified PUFA. In the first article, a process involving six edible oils, namely: olive, linseed, sunflower, evening primrose, DHASCO® and ARASCO® to obtain different monounsaturated FA (MUFA)- and PUFA- based MAG is described. The purification process starts with an enzymatic hydrolysis using porcine pancreatic lipase, then the reaction products were fractionated by using two liquid chromatography columns. The f...
In vitro antitumor