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dc.contributor.authorSánchez Martín, Victoria 
dc.contributor.authorSoriano Rodríguez, Miguel 
dc.contributor.authorGarcía Salcedo, José Antonio 
dc.date.accessioned2021-07-20T10:45:30Z
dc.date.available2021-07-20T10:45:30Z
dc.date.issued2021-06-24
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/10835/11929
dc.description.abstractNucleic acids can adopt alternative secondary conformations including four-stranded structures known as quadruplexes. To date, quadruplexes have been demonstrated to exist both in human chromatin DNA and RNA. In particular, quadruplexes are found in guanine-rich sequences constituting G-quadruplexes, and in cytosine-rich sequences forming i-Motifs as a counterpart. Quadruplexes are associated with key biological processes ranging from transcription and translation of several oncogenes and tumor suppressors to telomeres maintenance and genome instability. In this context, quadruplexes have prompted investigations on their possible role in cancer biology and the evaluation of small-molecule ligands as potential therapeutic agents. This review aims to provide an updated close-up view of the literature on quadruplex ligands in cancer therapy, by grouping together ligands for DNA and RNA G-quadruplexes and DNA i-Motifs.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcanceres_ES
dc.subjectG-quadruplexeses_ES
dc.subjecti-Motifses_ES
dc.titleQuadruplex Ligands in Cancer Therapyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/13/13/3156es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doihttps://doi.org/10.3390/cancers13133156


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional