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Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties
| dc.contributor.author | Hajji, Lazhar | |
| dc.contributor.author | Saraiba Bello, Cristóbal | |
| dc.contributor.author | Scalambra, Franco | |
| dc.contributor.author | Segovia Torrente, Gaspar Francisco | |
| dc.contributor.author | Romerosa Nievas, Antonio Manuel | |
| dc.date.accessioned | 2024-01-10T09:41:28Z | |
| dc.date.available | 2024-01-10T09:41:28Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | http://hdl.handle.net/10835/15051 | |
| dc.description.abstract | Complexes [RuCp(Adeninate–κN9)(mPTA)2](Cl0.5)(CF3SO3)2.5⋅H2O (1⋅H2O), [RuCp(Guaninate-κN7)(mPTA)2] (CF3SO3)2⋅H2O (2⋅H2O), [RuCp(Theophyllinate-κN7)(mPTA)2](CF3SO3)2⋅1.5H2O (3⋅1.5H2O) and [RuCp(Pur- κN)(mPTA)(PPh3)](CF3SO3) (4–6) (Pur = Adeninate, Guaninate, Teophyllinate; mPTA = N-methyl 1,3,5-triaza- 7-phosphaadamantane) have been synthesized and characterized. Structure of complexes 1⋅H2O and 3⋅1.5H2O were determined by single-crystal X-ray diffraction. Solubility in water, Log P, electrochemical properties and antiproliferative activities of the complexes (against cisplatin-sensitive T2 and cisplatin-resistant SKOV3 cell lines) have been assessed and discussed. | es_ES |
| dc.language.iso | en | es_ES |
| dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
| dc.source | Journal of Inorganic Biochemistry 218 (2021) 111404, DOI: https://doi.org/10.1016/j.jinorgbio.2021.111404 | es_ES |
| dc.subject | Antiproliferative activity | es_ES |
| dc.subject | Ruthenium | es_ES |
| dc.subject | Water-soluble complexes | es_ES |
| dc.subject | mPTA | es_ES |
| dc.subject | Natural purines | es_ES |
| dc.title | Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
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