Study of the biological activity of photoactive bipyridyl-Ru(II) complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA).
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Veiga Del Pino, Jose Manuel; Scalambra, Franco; Bermejo-Casadesús, Cristina; Massaguer, Anna; García Maroto, Federico; [et al.]Fecha
2023Resumen
The water-soluble ruthenium complex cis-[Ru(dcbpyH)2(PTAH)2]Cl2⋅3H2O (1) (dcbpy = 4,4′-dicarboxy-2,2′-
bipyridine; PTA = 1,3,5-triaza-7-phosphaadamantane) has been synthesized and characterised by NMR, IR
spectroscopy, elemental analysis, and single-crystal X-ray diffraction. The optical properties of 1 were studied,
including photoactivation under visible light, as well as its biological properties, together with those of the
previously published Ru complexes cis-[Ru(bpy)2(PTA)2]Cl2 (2), trans-[Ru(bpy)2(PTA)2](CF3SO3)2 (3) and cis-
[Ru(bpy)2(H2O)(PTA)](CF3SO3)2 (4) (bpy = 2,2′-bipyridine). Anticancer activities of the complexes against
human lung (A549), cervical (HeLa) and prostate (PC3) carcinoma cells were evaluated under dark conditions
and upon photoactivation with visible light. None of the complexes exhibited cytotoxic activity in the absence of
light irradiation (IC50 > 100 μM). However, after photoactivation, the cytotoxicity of complexes 1, 2 and 3
against the three...
Palabra/s clave
Ruthenium complexes
Anticancer
Photoactivation
Water-soluble complexes
PTA