Excessive habit formation in schedule-induced polydipsia: microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex
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URI: http://hdl.handle.net/10835/15225
DOI: https://doi.org/10.1111/gbb.12489
DOI: https://doi.org/10.1111/gbb.12489
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Merchán Carrillo, Ana María![Autoridad Universidad de Almería Autoridad Universidad de Almería](/themes/Mirage2/images/autoridades/autoridad.png)
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Fecha
2019-03-03Resumen
Schedule-induced polydipsia (SIP) is an animal model of compulsive drinking that selects for individual differences and varies across rat strains. The aim of this study was to investigate excessive habit formation by analyzing the SIP licking microstructure among rat strains, and to compare the brain areas activated by SIP in different populations. Wistar, Long Evans, and Roman High- and Low-Avoidance rat strains were compared using a cluster analysis of two main variables, i.e., frequency of licking (percentage of inter-pellet intervals with drinking episodes) and intensity of licking (mean number of licks per inter-pellet interval), and were found to exhibit high intensity and frequent licking (Compulsive Drinkers; CD), low intensity but frequent licking (Habitual Drinkers; HD), and low intensity and low frequency licking (Low Drinkers; LD). The Wistar strain showed a higher frequency and intensity of licking, and had the largest group of CD rats when compared to the other strains. R...
Palabra/s clave
Schedule-induced Polydipsia
Compulsivity
Habit formation
Inhibitory Control
Strain Comparison
Individual Differences
Licking
Roman high- and low-avoidance rats
Orbitofrontal Cortex
Amygdala