Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia
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URI: http://hdl.handle.net/10835/15265
ISSN: 02785846
DOI: https://doi.org/10.1016/j.pnpbp.2019.03.016
ISSN: 02785846
DOI: https://doi.org/10.1016/j.pnpbp.2019.03.016
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Merchán Carrillo, Ana María; Sánchez Kuhn, Ana; Prados Pardo, Ángeles; Gago Calderón, Belén; Sánchez Santed, Luis Fernando; [et al.]Date
2019-03-30Abstract
Schedule-induced polydipsia (SIP), characterized by the development of persistent and excessive drinking under intermittent food-reinforcement schedules, is an animal model of compulsive behavior that can differentiate two populations: high drinkers (HD) and low drinkers (LD). The aim of the present study was to identify behavioral and biological markers to predict the vulnerability to developing compulsive-like drinking in SIP. Adult male Wistar rats were first trained in a spatial-discrimination serial reversal-learning task and in a reinforcer devaluation task to measure behavioral flexibility and habit formation, respectively. Subsequently, the rats were tested using the SIP protocol and identified as HD or LD based on their drinking rates. The performance of HD and LD rats in the two previous tasks was then analyzed. Before and after SIP exposure, blood glucose and plasma corticosterone (CORT) levels were measured. Additionally, serum electrolyte levels, including sodium, potassiu...
Palabra/s clave
Schedule-induced Polydipsia
Compulsivity
Reversal Learning
Reinforcer Devaluation
Corticosterone