Dopamine Innervation in the Thalamus: Monkey versus Rat
Ficheros
Identificadores
Compartir
Metadatos
Mostrar el registro completo del ítemAutor
García Cabezas, Miguel; Martínez Sánchez, Patricia; Sánchez González, Miguel Ángel; Garzón, Miguel; Cavada, CarmenFecha
2009-02-01Resumen
We recently identified the thalamic dopaminergic system in the human and macaque monkey brains, and, based on earlier reports on the paucity of dopamine in the rat thalamus, hypothesized that this dopaminergic system was particularly developed in primates. Here we test this hypothesis using immunohistochemistry against the dopamine transporter (DAT) in adult macaque and rat brains. The extent and density of DAT-immunoreactive (-ir) axons were remarkably greater in the macaque dorsal thalamus, where the mediodorsal association nucleus and the ventral motor nuclei held the densest immunolabeling. In contrast, sparse DAT immunolabeling was present in the rat dorsal thalamus; it was mainly located in the mediodorsal, paraventricular, ventral medial, and ventral lateral nuclei. The reticular nucleus, zona incerta, and lateral habenular nucleus held numerous DAT-ir axons in both species. Ultrastructural analysis in the macaque mediodorsal nucleus revealed that thalamic interneurons are a mai...
Palabra/s clave
dopamine
macaque
rat
species differences
thalamus