Unravelling the capacity of hydroxytyrosol and its lipophenolic derivates to modulate the H2O2-induced isoprostanoid profile of THP-1 monocytes by UHPLC-QqQ-MS/MS lipidomic workflow
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Alemán-Jiménez, Carolina; Domínguez-Perles, Raúl; Fanti, Federico; Gallego Gómez, Juana Inés; Simonelli Muñoz, Agustín Javier; [et al.]Fecha
2021-11-01Resumen
Presently, the attention given to natural substances to counteract damage produced by oxidative stress (OS) has
risen sharply. In this scenario, hydroxytyrosol (HT) derivatives, formed as a result of HT conjugation with fatty
acids (FAs) (lipophenols), have been recently described in foodstuffs such as extra virgin olive oil, as being
powerful bioactive compounds with a higher activity than the unesterified phenolic compound. The present work
describes the capacity of HT lipophenols to act on the course of OS and secondary inflammatory processes, based
on their capacity to modulate the isoprostanoid profile induced by H2O2 in THP-1 monocytic cells. A UHPLCQqQ-ESI-MS/MS-based lipidomics workflow was applied over a range of 37 human oxylipins. The main outcomes retrieved suggest both HT and HT-lipophenols as regulators of the cellular redox balance, acting as prooxidants in vitro, which is highly dependent on the experimental conditions. Our outcomes suggest the antiinflammatory pot...
Palabra/s clave
Hydroxytyrosol
Lipophenols
In vitro models
Isoprostanoids
Oxidative stress
Inflammation