A Practical, Large-Scale Synthesis of Pyrene-2-Carboxylic Acid
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Casas Solvas, Juan Manuel![Autoridad Universidad de Almería Autoridad Universidad de Almería](/themes/Mirage2/images/autoridades/autoridad.png)
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2014-10-02Resumen
Pyrene-2-carboxylic acid is a versatile intermediate for introducing the unusual 2-pyrenyl unit into functional organic molecules. A classical preparation for this molecule has been revised and improved to give a robust and efficient three-step process. The method has been applied on a multigram scale to give pyrene-2-carboxylic acid in >70% overall yield from pyrene.
Palabra/s clave
Pyrene
condensed aromatic compounds
electrophilic aromatic substitution
ring closure
ring opening
Haller–Bauer cleavage