Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active substances
Identificadores
Compartir
Metadatos
Mostrar el registro completo del ítemAutor
Augis, Luc; Reiten, Ingeborg Nerbø; Førde, Jan-Lukas; Casas Solvas, Juan Manuel![Autoridad Universidad de Almería Autoridad Universidad de Almería](/themes/Mirage2/images/autoridades/autoridad.png)
Fecha
2024-01-15Resumen
Although amphiphilic cyclodextrin derivatives (ACDs) serve as valuable building blocks for nanomedicine formulations, their widespread production still encounters various challenges, limiting large-scale manufacturing. This work focuses on a robust alternative pathway using mineral base catalysis to transesterify β-cyclodextrin with long-chain vinyl esters, yielding ACD with modular and controlled hydrocarbon chain grafting. ACDs with a wide range of degrees of substitution (DS) were reliably synthesized, as indicated by extensive physicochemical characterization, including MALDI-TOF mass spectrometry. The influence of various factors, including the type of catalyst and the length of the hydrocarbon moiety of the vinyl ester, was studied in detail. ACDs were assessed for their ability to form colloidal suspensions by nanoprecipitation, with or without PEGylated phospholipid. Small-angle X-ray scattering and cryo-electron microscopy revealed the formation of nanoparticles with distinct ...
Palabra/s clave
Amphiphilic cyclodextrin
Nanoparticles
PEGylation
Complement activation
Zebrafish larvae