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Synthesis of Spironucleosides: Past and Future Perspectives
dc.contributor.author | González Soengas, Raquel María | |
dc.contributor.author | Da Silva, Gustavo | |
dc.contributor.author | Estévez, Juan Carlos | |
dc.date.accessioned | 2020-01-16T09:32:29Z | |
dc.date.available | 2020-01-16T09:32:29Z | |
dc.date.issued | 2017-11-22 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | http://hdl.handle.net/10835/7348 | |
dc.description.abstract | Spironucleosides are a type of conformationally restricted nucleoside analogs in which the anomeric carbon belongs simultaneously to the sugar moiety and to the base unit. This locks the nucleic base in a specific orientation around the N-glycosidic bond, imposing restrictions on the flexibility of the sugar moiety. Anomeric spiro-functionalized nucleosides have gained considerable importance with the discovery of hydantocidin, a natural spironucleoside isolated from fermentation broths of Streptomyces hygroscopicus which exhibits potent herbicidal activity. The biological activity of hydantocidin has prompted considerable synthetic interest in this nucleoside and also in a variety of analogues, since important pharmaceutical leads can be found among modified nucleoside analogues. We present here an overview of the most important advances in the synthesis of spironucleosides. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | spironucleosides | es_ES |
dc.subject | spirohydantoins | es_ES |
dc.subject | spirodiketopiperazines | es_ES |
dc.subject | sugar amino acids | es_ES |
dc.title | Synthesis of Spironucleosides: Past and Future Perspectives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/22/11/2028 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |