A Concise Route for the Synthesis of Tetracyclic Meroterpenoids: (±)-Aureol Preparation and Mechanistic Interpretation
Identificadores
Compartir
Metadatos
Mostrar el registro completo del ítemAutor
Rosales Martínez, Antonio; Enríquez, Lourdes; Jaraíz, Martín; Pozo Morales, Laura; Rodríguez García, Ignacio Manuel![Autoridad Universidad de Almería Autoridad Universidad de Almería](/themes/Mirage2/images/autoridades/autoridad.png)
Fecha
2020-08-26Resumen
A new concise general methodology for the synthesis of different tetracyclic meroterpenoids is reported: (±)-aureol (1), the key intermediate of this general route. The synthesis of (±)-aureol (1) was achieved in seven steps (28% overall yield) from (±)-albicanol. The key steps of this route include a C–C bond-forming reaction between (±)-albicanal and a lithiated arene unit and a rearrangement involving 1,2-hydride and 1,2-methyl shifts promoted by BF3•Et2O as activator and water as initiator.
Palabra/s clave
aureol
tetracyclic meroterpenoids
natural products synthesis