The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6C10H14)(Cl2)(dmoPTA)]
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2022Resumen
Complexes [Ru(η6 C10H14)(Cl2)(HdmoPTA)](OSO2CF3)
(1), [Ru(η6 C10H14)(Cl2)(dmoPTA)] (2) and [Ru(η6 C10H14)(Cl2)-μ-
dmoPTA-1kP:2k2N,N’-MCl2] (M=Zn (3), Co (4), Ni (5), dmoPTA=
3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)
have been synthesized and characterized by elemental
analysis and spectroscopic techniques. The crystal structures
of 1, 3 and 5 were obtained by single-crystal X-ray diffraction.
The antiproliferative activity of the complexes was evaluated
against colon cancer cell line Caco-2/TC7 by using the MTT
protocol. The monometallic ruthenium complexes 1 and 2
were found to be inactive, but the bimetallic complexes 3, 4
and 5 display an increased activity (IC50 3: 9.07�0.27, 4:
5.40�0.19, 5: 7.15�0.30 μM) compared to cisplatin (IC50=
45.6�8.08 μM). Importantly, no reduction in normal cell
viability was observed in the presence of the complexes.
Experiments targeted to obtain information on the possible
action mechanism of the complexes, such as...