Dietary tryptophan depletion alters the faecal bacterial community structure of compulsive drinker rats in schedule-induced polydipsia
Files
Identifiers
URI: http://hdl.handle.net/10835/15264
ISSN: 00319384
DOI: https://doi.org/10.1016/j.physbeh.2021.113356
ISSN: 00319384
DOI: https://doi.org/10.1016/j.physbeh.2021.113356
Share
Metadata
Show full item recordAuthor/s
Merchán Carrillo, Ana María; Pérez Fernández, Cristian Antonio; López López, María José; Moreno Casco, José Joaquín; Moreno Montoya, Margarita Begoña; [et al.]Date
2021-02-10Abstract
Rationale: Compulsive behaviour, present in different psychiatric disorders such as obsessive-compulsive disorder, schizophrenia and drug abuse, is associated with altered levels of serotonin (5-hydroxytryptamine, 5-HT). The gut microbiota regulates tryptophan (TRP) metabolism and may affect global 5-H synthesis in the enteric and central nervous systems, suggesting a possible involvement of gut microbiota in compulsive spectrum disorders.
Objectives: The present study investigated whether chronic TRP depletion by diet alters the faecal bacterial community profiles of compulsive versus non-compulsive rats in schedule-induced polydipsia (SIP). Peripheral plasma 5-HT and brain-derived neurotrophic factor (BDNF) levels were evaluated.
Methods: Wistar rats were selected as High Drinkers (HD) or Low Drinkers (LD) according to their SIP behaviour and were fed for 14 days with either a TRP-free diet (T-) or a TRP-supplemented diet (T+). The faecal bacterial community structure was investi...
Palabra/s clave
Compulsivity
Schedule-induced polydipsia
Gut microbiota
Chronic tryptophan depletion
PCR-DGGE
Brain-derived neurotrophic factor