Treatment with angiotensin receptor blockers before stroke could exert a favourable effect in acute cerebral infarction
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Fuentes, Blanca; Fernández Domínguez, Jéssica; Ortega Casarrubios, María Ángeles; SanJosé, SanJosé, Belén; Martínez Sánchez, Patricia; [et al.]Fecha
2010-03-01Resumen
Introduction: Evidence from experimental and clinical studies is accumulating about the possible cerebral protective properties of antihypertensive drugs, mainly angiotensin receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI). Our aim was to analyse the impact of prestroke use of antihypertensive drugs on stroke severity and outcome.
Methods: We analysed 1968 consecutive patients with first-ever acute cerebral infarction admitted to an acute stroke unit. Stroke severity was evaluated using the Canadian Neurological Scale and the modified Rankin Score (mRS) was used to evaluate the outcome at discharge.
Results: Previous diagnosis of arterial hypertension was reported in 1212 patients and 73% were on antihypertensive treatment. No significant differences in stroke severity were found between patients with or without previous arterial hypertension, either in patients with or without antihypertensive treatment. Patients taking antihypertensive drugs at stroke ...
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angiotensin receptor blockers, antihypertensive drugs, stroke, stroke outcome, stroke severity