Phenolic composition and in vitro antiproliferative activity of Borago spp. seed extracts on HT-29 cancer cells
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URI: http://hdl.handle.net/10835/15867
DOI: https://doi.org/10.1016/j.fbio.2021.101043
DOI: https://doi.org/10.1016/j.fbio.2021.101043
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Lyashenko, Svetlana; Fabrikov, Dimitri; González Fernández, María José; Gómez Mercado, Francisco; López Ruiz, Rosalía; [et al.]Date
2021-04-20Abstract
Borage oil contains γ-linolenic acid (GLA, 18:3n-6), and significant amounts of tocopherols, sterols and squalene. However, data on phenolics are absent for most Borago species, while such compounds are relevant for improving human health. In this work, seeds of all endemic-wild Borago species and wild and farmed B. officinalis were surveyed for phenolic compound composition and in vitro antiproliferative activities. Phenolic analyses were conducted by HPLC-DAD and LC-MS, and antitumor actions were checked by the MTT assay. Besides a flavonol (kaemferol), 13 phenolic acids were identified and quantified. Among B. officinalis samples, the highest amounts of total phenolics and rosmarinic acid were found in the warmest and southernmost localities. Rosmarinic acid ranged from 12.21 (B. officinalis 'Alba' B2) to 105.06 mg/100 g seed (B. longifolia). Ferulic acid was also found in all Borago species, ranging from 1.38 in wild B. officinalis to 55.98 mg/100 g seed in B. longifolia. The MTT a...
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Organic Chemistry
food technology