NIS−PPh3: A Selective Reagent for the Spiroannulation of o‑Allyl Phenols. Total Synthesis of Corallidictyal D
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Cano, M. José; Bouanou, Hanane; Tapia, Rubén; Alvarez, Esteban; Alvarez-Manzaneda Roldán, Ramón Jesús; [et al.]Fecha
2013-08-28Resumen
Treatment of o-allyl phenols with catalytic NIS−PPh3 affords the corresponding spirodihydrobenzofuran derivatives in high yield with high regio- and total stereoselectivity under mild conditions. These results were utilized to achieve the first total synthesis of the protein kinase C inhibitor corallidictyal D starting from α-ionone.