CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties.
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Hajji, Lazhar; Saraiba-Bello, Cristobal; Segovia-Torrente, Gaspar; Scalambra, Franco; Romerosa, AntonioDate
2019-09-17Abstract
Complexes [RuCp(Adeninate-κN9)(PTA)2] (1), [RuCp-
(Guaninate-κN9)(PTA)2] (2), [RuCp(Theophyllinate-κN7)(PTA)2]
(3), [RuCp(Adeninate-κN9)(PPh3)(PTA)] (4), [RuCp(Guaninate-
κN9)(PPh3)(PTA)] (5) and [RuCp(Theophyllinate-κN7)(PPh3)(PTA)]
(6) were synthesized and characterized by NMR spectroscopy,
elemental analysis and FT-IR (PTA = 1,3,5-triaza-7-phosphaadamantane).
Crystal structures of 1·H2O·3EtOH, 3·CH3COCH3
and 4·H2O were also determined by single-crystal X-ray diffraction.
The antiproliferative activities of the complexes against
cisplatin-sensitive T2 and cisplatin-resistant SKOV3 cell lines
have also been evaluated. Theoretical studies were preformed
to elucidate how the adeninate ligand is coordinated to the
metal.