Stereoselective Barbier Type Allylations and Propargylations Mediated by CpTiCl3
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URI: http://hdl.handle.net/10835/14713
DOI: https://doi.org/10.1021/acs.joc.8b02643
DOI: https://doi.org/10.1021/acs.joc.8b02643
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López Martínez, Josefa Leticia; Torres García, Irene; Rodríguez García, Ignacio Manuel; Muñoz Dorado, Manuel; Álvarez Corral, MíriamFecha
2019Resumen
CpTiCl2, prepared in situ by manganese reduction of CpTiCl3, is an excellent new system for the Barbier-type allylation and propargylation of carbonyl compounds. It can be used in catalytic amounts when combined with Et3N•HBr/TMSBr, which act as regenerating system. The high regio- and stereoselectivity shown by this system makes it useful for prenylation and crotylation processes in synthesis of natural products.
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Organic Chemistry