A non‐covalent “click chemistry” strategy to efficiently coat highly porous MOF nanoparticles with a stable polymeric shell
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Aykac, Ahmet; Noiray, Magali; Malanga, Milo; Agostoni, Valentina; Casas Solvas, Juan Manuel; [et al.]Fecha
2017-01-16Resumen
Background
Metal-organic framework nanoparticles (nanoMOFs) are biodegradable highly porous materials with a remarkable ability to load therapeutic agents with a wide range of physico-chemical properties. Engineering the nanoMOFs surface may provide nanoparticles with higher stability, controlled release, and targeting abilities. Designing postsynthetic, non-covalent self-assembling shells for nanoMOFs is especially appealing due to their simplicity, versatility, absence of toxic byproducts and minimum impact on the original host-guest ability.
Methods
In this study, several β-cyclodextrin-based monomers and polymers appended with mannose or rhodamine were randomly phosphorylated, and tested as self-assembling coating building blocks for iron trimesate MIL-100(Fe) nanoMOFs. The shell formation and stability were studied by isothermal titration calorimetry (ITC), spectrofluorometry and confocal imaging. The effect of the coating on tritium-labeled AZT-PT drug release was estimated ...
Palabra/s clave
MIL-100(Fe) nanoMOFs
β-Cyclodextrin
Phosphorylation
Non-covalent coating
AZT-TP