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CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties.
dc.contributor.author | Hajji, Lazhar | |
dc.contributor.author | Saraiba-Bello, Cristobal | |
dc.contributor.author | Segovia-Torrente, Gaspar | |
dc.contributor.author | Scalambra, Franco | |
dc.contributor.author | Romerosa, Antonio | |
dc.date.accessioned | 2019-11-12T09:41:19Z | |
dc.date.available | 2019-11-12T09:41:19Z | |
dc.date.issued | 2019-09-17 | |
dc.identifier.uri | http://hdl.handle.net/10835/7253 | |
dc.description.abstract | Complexes [RuCp(Adeninate-κN9)(PTA)2] (1), [RuCp- (Guaninate-κN9)(PTA)2] (2), [RuCp(Theophyllinate-κN7)(PTA)2] (3), [RuCp(Adeninate-κN9)(PPh3)(PTA)] (4), [RuCp(Guaninate- κN9)(PPh3)(PTA)] (5) and [RuCp(Theophyllinate-κN7)(PPh3)(PTA)] (6) were synthesized and characterized by NMR spectroscopy, elemental analysis and FT-IR (PTA = 1,3,5-triaza-7-phosphaadamantane). Crystal structures of 1·H2O·3EtOH, 3·CH3COCH3 and 4·H2O were also determined by single-crystal X-ray diffraction. The antiproliferative activities of the complexes against cisplatin-sensitive T2 and cisplatin-resistant SKOV3 cell lines have also been evaluated. Theoretical studies were preformed to elucidate how the adeninate ligand is coordinated to the metal. | es_ES |
dc.language.iso | en | es_ES |
dc.relation | info:eu-repo/grantAgreement/ES/MINECO/CTQ2015-67384-R/ES/Polímeros poliheteroorganmetálicos fluorecentes solubles en agua/PPFSA | es_ES |
dc.source | Eur. J. Inorg. Chem. 2019, 4078–4086 | es_ES |
dc.title | CpRu Complexes Containing Water Soluble Phosphane PTA and Natural Purines Adenine, Guanine and Theophylline: Synthesis, Characterization, and Antiproliferative Properties. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/ejic.201900677 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1002/ejic.201900677 |